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¹ Republic of Turkey Ministry of Agriculture and Forestry Central Fisheries Research Institute Kasustu, Yomra, 61250, TRABZON
² Kadalamma-Centre for Ocean Sustainability Research, Education and Training, Thumba, Thiruvananthapuram, Kerala, India-695022 DOI : 10.4194/2459-1831-v3_2_05 Viewed : 2640 - Downloaded : 2834 Toll-like receptors (TLRs) are one of the important components of innate immune system involved in pathogen recognition. Aquaculture species encounter potential diseases caused by pathogens resulting in great economic loss for producers. Asian seabass is a significant aquaculture species, but there is not enough information about their TLR repertoire to comprehend the underlying molecular regulation of pathogen recognition for effective measurements. In this study, members of TLR family in Asian seabass were identified by genome mining to provide basic information for future studies on pathogen recognition receptor-driven signaling in Asian seabass. Then phylogenetic and conserved domain analysis were constructed for predicted TLRs. Analysis resulted with identification of 17 TLR gene that includes mammals and fish specific TLRs and four of the TLR genes (TLR2, TLR5, TLR22, TLR23) had more than one copy. Phylogenetic analysis showed that Asian seabass predicted TLRs made group with their counterparts from other teleost and mammals and also, predicted TLRs exhibit an expected conserved structure. These results mean that TLR family were conserved and even expanded because of selective pressure caused by pathogen in distinct habitat. Keywords : Genome mining, PRRs, Lates calcarifer, TLR, Innate immunity